MDMA Research Exclusion Criteria

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Criteria Used in recent studies Source
Pre-existing uncontrolled hypertension Yes MAPS Investigator’s Brochure 8th Edition (2016)
Known cardiovascular or cerebrovascular disease Yes MAPS Investigator’s Brochure 8th Edition (2016)
Recent use of MAOIs (see time frame) Yes MAPS Investigator’s Brochure 8th Edition (2016)
Actual or possible pregnancy Yes "Since there may be a critical period during which exposure to MDMA could alter development, and as a result of the relative lack of information concerning its developmental toxicity, women who are pregnant or who are not using an effective means of birth control should not receive MDMA in clinical trials. None of the sponsor’s studies enroll pregnant or lactating subjects."

MAPS Investigator’s Brochure 8th Edition (2016)

Heart disease Not sure Subjective Reports of the Effects of MDMA in a Clinical Setting (1986)
Hyperthyroidism Not sure Subjective Reports of the Effects of MDMA in a Clinical Setting (1986)
Diabetes mellitus Not sure Subjective Reports of the Effects of MDMA in a Clinical Setting (1986)
Hypoglycemia Not sure Subjective Reports of the Effects of MDMA in a Clinical Setting (1986)
Seizure disorder Not sure Subjective Reports of the Effects of MDMA in a Clinical Setting (1986)
Diminished liver function Not sure Subjective Reports of the Effects of MDMA in a Clinical Setting (1986)
A history of a socially or vocationally disabling psychological condition Not sure Subjective Reports of the Effects of MDMA in a Clinical Setting (1986)
Inability to sustain moderate exercise Not sure -
Sensitivity to heatstroke (e.g. Central core disease) Not sure -
Use of CYP2D6 drugs (e.g. Bupropion/Wellbutrin, Ritonavir/Norvir) Not sure See the FDA’s table of strong, moderate and weak CYP2D6 inhibitors.

One death involving MDMA and ritonavir, with CYP2D6 inhibition possibly playing a role, but possibly not

Anhidrosis/hypohydrosis (inability to sweat normally) Not sure *
Malignant hyperthermia Not sure *
Any other conditions that would impact your ability for your body to regulate temperature Not sure -