MAOIs, SSRIs and MDMA

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MAOIs[edit]

You should wait 3 weeks after the last time you took an MAOI before taking MDMA. This is very important.

Common MAOIs[edit]

Isocarboxazid (Marplan) Phenelzine (Nardil) Selegiline (Emsam) Tranylcypromine (Parnate) [1]

MAPS Research Guidance[edit]

“Fatalities have occurred apparently as a result of combining MAOI medications with MDMA [133, 134]. For this reason, MAOI medications are tapered for at least five half lives of the medication and active metabolites, plus 1 week for symptom stabilization in sponsor-supported studies.” – MAPS 2016 Brochure

SSRIs[edit]

SSRIs will reduce or eliminate the subjective effects of MDMA, so you'll want to wait until you feel back to 'normal' after tapering down SSRI use.

See this guide and this guide for SSRI tapering information.

Common SSRIs[edit]

  • Citalopram (Celexa)
  • Escitalopram (Lexapro)
  • Fluoxetine (Prozac)
  • Paroxetine (Paxil, Pexeva)
  • Sertraline (Zoloft)
  • Vilazodone (Viibryd) [2]

MAPS Research Guidance[edit]

"Co-administration with an SSRI may eliminate or greatly attenuate the effects of MDMA, and these medications should be tapered in line with the investigator’s clinical judgment and an approved study protocol." – MAPS 2016 Brochure

References[edit]

  1. http://www.mayoclinic.org/diseases-conditions/depression/in-depth/maois/art-20043992
  2. http://www.mayoclinic.org/diseases-conditions/depression/in-depth/ssris/art-20044825